Association between Adiponectin, Serum Lipids and Obesity in a University Setting in Nigeria

F L Ciroma, J O Ayo, A Mohammed, M B Akor-Dewu, M A Kana, S N Kase

Abstract


Obesity is an energy imbalance condition, which is accompanied by metabolic and cardiovascular complications.
Adiponectin, produced by adipocytes, is an important adipokine involved in carbohydrate and lipid metabolism. Adiponectin
level is altered in obesity in various populations. In Nigeria, very few studies regarding adiponectin exist, and none, to the
best of our knowledge, investigated the relationship between adiponectin and lipid profile and obesity. Therefore, this study
aims to evaluate changes in adiponectin level and serum lipids with body mass index, and investigate the relationship between
adiponectin, serum lipids and obesity in Nigerian adults. Anthropometric parameters and blood pressure were measured, and
blood samples were collected for biochemical assessment after 12 hours fasting, in a total of 280 subjects, comprising of 186
males and 94 females. Serum adiponectin level was evaluated by ELISA, while serum lipid profile was determined by
enzymatic endpoint method. Quantitative data were analyzed for significant difference using ANOVA, and Pearson’s
correlation was used to evaluate relationships. Serum adiponectin level was significantly (P ˂ 0.05) highest within overweight
male subjects (1.6 ± 0.06 µg/ml), and lowest within normal male subjects (1.4 ± 0.03 µg/ml). The values for adiponectin
concentrations were not significantly different in the female subjects. There was no association in serum lipids and
adiponectin in both male (r = -0.035, P >0.05; r = -0.011, P >0.05; r = -0.053, P >0.05; r = -0.084, P >0.05) and female (r
=0.061, P >0.05; r = 0.018, P>0.05; r = 0.057, P>0.05; r = -0.021, P >0.05) for LDL, HDL, TC and TRIG respectively. Lipid
profile was not different across BMI classes. There was no relationship between adiponectin and serum lipids in individuals
in the study population of adult Nigerians.

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