Ahaptoglobinaemia in a Nigerian Cohort

Chidiebere C Eluke, Blessing C Eluke, Ndidiamaka I Okereke, Chukwugozie Okwuosa, Silas Ufelle

Abstract


Ahaptoglobinaemia have been indicated in blacks from West Africa. Owing to the clinical and biologic
importance of haptoglobin (hpt), this work explores the situation in a Nigerian cohort since there are no published values of
haptoglobin levels of individuals in this locality. The study was aimed at determining the amount of haptoglobin in the blood
of normal healthy Nigerians. Haptoglobin was quantitatively estimated in one hundred and fifty-two apparently healthy
individuals using highly sensitive immunoassay technology. Blood grouping and haemoglobin genotype were assayed for
all subjects to know if they influence haptoglobin levels. The association between haptoglobin and blood group was also
established. Serum levels of haptoglobin among all subjects analyzed revealed a marked decrease in their haptoglobin levels
when compared to other reference intervals. A further association between haptoglobin and gender did not reveal a statistical
significant relationship (p>0.05). However, there was a significant different when haptoglobin levels of different blood
groups and haemoglobin genotype when compared. Our data suggest that serum levels of haptoglobin are significantly lower
in healthy Nigerians. The lower limit was remarkably lower than the internationally acceptable Caucasian reference range
suggesting a clear necessity for establishing reference African values.


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